South Africa stands tall as the center of affluence in Africa, commanding a remarkable $650 billion in private wealth. As the continent’s richest market and industrial powerhouse, it’s no surprise that this country has produced brilliant thinkers who have crossed borders and benefited civilizations.
Visionary South Africans who have created an indelible mark in the pharmaceutical world, driving billion-dollar firms that resonate globally, are among these changemakers. Stephen Saad, the brains behind Africa’s largest pharmaceutical conglomerate, Aspen Pharmacare, is leading the charge. Saad has built a billion-dollar enterprise, solidifying his status as one of Africa’s leading pharmaceutical tycoons.
Ivan and Lynette Saltzman’s strong partnership has catapulted Dis-Chem Pharmacies to new heights. With over 300 outlets, they’ve carved out a renowned retail chain that reaches across Africa.
South African-American billionaire Patrick Soon-Shiong emerges as a pharmaceutical industry leader after entering the critical field of cancer treatment. Soon-Shiong, who was born in South Africa and now has a net worth of $9.21 billion, has revolutionized cancer therapy. The apex of his creation is Abraxane, a game-changing cancer treatment that has received widespread recognition.
HowAfrica spotlights five South African trailblazers, visionary thinkers that have not only built pharmaceutical firms worth billions of dollars, but have also moved South Africa into the world arena of medical innovation.
1. Stephen Saad

Founder of Aspen Pharmacare
Stephen Saad is a pioneering entrepreneur and the co-founder of Aspen Pharmacare, Africa’s largest pharmaceutical company. Aspen Pharmacare has achieved extraordinary success under his innovative leadership, operating in 150 countries and establishing itself as a global producer and distributor of generic medications.
In 1999, Saad and Gus Attridge began their entrepreneurial journey by purchasing local pharmacies. This first venture quickly moved from Durban to the international scene, propelling Aspen Pharmacare’s astonishing growth into a billion-dollar pharmaceutical behemoth. In 2003, the business pioneered the creation of Africa’s first generic antiretroviral HIV medicine, followed by entry into the infant formula industry.
Saad’s unwavering commitment to Aspen Pharmacare is shown by his 12.5 percent ownership position in the company, which is valued at about $553.3 million, reflecting his significant contribution to the company’s continued legacy.
2. Patrick Soon-Shiong

Founder of ImmunityBio
Patrick Soon-Shiong, a billionaire from South Africa, has made an unmistakable influence on the global healthcare business. Soon-Shiong’s net worth of $8.98 billion is reflected in his groundbreaking accomplishments. He is the creator of the groundbreaking cancer drug Abraxane and the founder of the pharmaceutical businesses APP Pharmaceuticals and Abraxis BioScience.
These ventures were successfully sold for a total of $7.5 billion. Soon-Shiong, who currently owns 76 percent of the publicly traded late-stage immunotherapy business ImmunityBio, continues to impact the field. ImmunityBio, launched in 2014, is a pioneer in cancer and infectious illness immunotherapies. Soon-Shiong’s legacy lives on through his pioneering pursuits, which are valued at $1.6 billion.
3. Ivan Saltzman

Founder of Dis-Chem Pharmacies
Dis-Chem Pharmacies, a major name in the South African pharmaceutical sector, is led by Ivan Saltzman, a visionary entrepreneur, and his wife Lynette. Ivan and Lynette Saltzman co-founded the company in 1978, and their persistent efforts have catapulted Dis-Chem from humble beginnings to a wide network of over 300 retail locations and a workforce of over 20,000 specialists.
Ivan Saltzman is one of South Africa’s most prominent investors, owning 35.12 percent of the company. The Saltzmans have gained tremendous financial advantages from their significant ownership over the past 45 years.
The Saltzmans’ commitment to improving South Africa’s healthcare and pharmacy retail sectors is reflected in Dis-Chem’s broad offerings, which include linked dispensaries, family clinics, wound care facilities, and self-medication hubs.
4. Gus Attridge

Co-Founder of Aspen Pharmacare
Gus Attridge’s entrepreneurial abilities are highlighted by his co-founding involvement in Aspen Pharmacare, a disruptive force in the pharmaceutical business, with Stephen Saad. Founded in 1997, this enterprise has grown to become one of the world’s largest generic drugmakers under Attridge’s leadership.
As deputy CEO and finance director, Attridge has led Aspen Pharmacare’s global expansion through strategic acquisitions since 2013, building a global footprint with production facilities in Australia, Brazil, Mexico, Germany, South Africa, and Tanzania.
With a significant 4.28 percent ownership position, Attridge’s contributions are critical to the company’s $4.56 billion valuation. His $195 million stake demonstrates his steadfast dedication to Aspen Pharmacare’s expansion and success.
5. Lynette Saltzman

Co-Founder of Dis-Chem Pharmacies
Lynette Saltzman is a significant leader in South Africa’s pharmaceutical business and was essential in the creation of Dis-Chem Pharmacies. Her collaborative efforts in starting Dis-Chem with her husband, Ivan, in 1978 propelled the company’s journey to become a major name in the African healthcare sector.
Lynette’s early efforts and ongoing leadership have been critical in growing Dis-Chem’s reach to include a sprawling network of over 300 retail stores and a team of over 20,000 specialists.
The Saltzmans’ indirect 35.12% interest in Dis-Chem Pharmacies places them among South Africa’s most powerful investors. Their consistent dividend accumulation from this stake highlights their financial gains. Lynette Saltzman’s legacy is imprinted in the company’s continuing success, with Dis-Chem’s current market valuation standing at $1.11 billion.