Kaweesi, the police spokesman, was shot dead on Friday morning alongside his driver Godfrey Wambewo and his bodyguard Kenneth Erau.
According to New Vision media, gunmen shot the trio as they left his his Kulambiro home in Kampala suburb to work in his official car.
Kaweesi was heading to Uganda Christian University to speak to students but he did not show up.
“He (Kaweesi) was waylaid this morning by yet unknown gunmen. All the occupants of the vehicle were killed,” government spokesperson Ofwono Opondo said.
No further details were immediately available and the motive of the gunmen was unclear.
Kampala Metropolitan Police spokesperson Emirian Kayima confirmed the murders, adding investigations have been launched.
The bodies have been removed from the scene and taken to the mortuary.
United States Embassy Uganda has condemned the attack saying there is no justification for the murders.
“There is no justification for violence or murder. We hope police will find and bring to justice those responsible for this crime,” the Mission said via twitter.
The embassy extended its condolences to the family at the police fraternity.
“We are saddened and distressed by news of AIGP Kaweesi’s death and extend deepest condolences,” they said.
Kaweesi gained a prominent public profile when, as head of police operations in greater Kampala, he oversaw frequent arrests ofUganda‘s main opposition figure, Kizza Besigye.