The 41-year-old former Ismaily manager arrived in Kampala just hours after leading the Egyptian side to a 5-1 win over El Raja in his final match for them.
“I’ve worked for a long time in Africa and I know a lot about African football. I am ready to serve the Cranes.”
He resigned from his position at Ismaily, an indication that he has reached an agreement with the East African team.
Desabre was among four men shortlisted by FUFA for the position on December 22. The others were current interim coach Moses Basena, Johnny McKinstry from Northern Ireland and Belgian Emilio Ferrera.
The French side has never coached a national team, but has a lot of club experience from coaching a number of clubs in North Africa.
The selection of Uganda Cranes coach was spearheaded by Zambia’s Kalusha Bwalya, who worked with a five-man technical committee.
The Cranes have been without a fulltime coach since Milutin ‘Micho’ Sredojevic terminated his contract over the issue of unpaid wages in July.