The Juventus forward was among the first Serie A players to contract Covid-19 alongside team-mates Daniele Rugani and Blaise Matuidi.
He confirmed to his 37.9million Instagram followers on March 21 that both he and girlfriend Oriana Sabatini had caught the disease.
But Spanish programme El Chiringuito stated Dybala has had four tests across the last six weeks and the latest one was positive again.
It is unclear when each of those tests took place, if Sabatini has also been tested as regularly or if either of them are still displaying symptoms.
They do appear in high spirits though, with Dybala’s Instagram story showing the striker working out in a home gym and then the pair doing a TikTok dance together, days after they welcomed dog Kaia to the family.
The reports come just days after Juventus got in touch with their players who had travelled back to their homelands for the lockdown.
Cristiano Ronaldo and Douglas Costa were among those to be called back to Turin as Juventus look to try and return to training, as teams in Germany and England have done.
But those stars arriving back in Italy will need to go into quarantine for a further two weeks before they can reunite with their team-mates at the training ground.
Serie A sides are allowed to return to individual training on May 4 and team training on May 18.
That is after Italian prime minister Giuseppe Conte announced the primary stages of lifting the country’s lockdown.
Italy was the first European epicentre for the virus and have seen 202,000 confirmed cases with 27,359 deaths.
Early in April, Sabatini revealed she had taken a test which came back with a “false negative” but a further test showed she still had Covid-19.