A study published by the National Academy of Sciences confirmed that ibuprofen has a negative impact on the testicles of young men, which would cause impotence. According to Inserm researchers, the substance found in many anti-inflammatory drugs would cause hormonal imbalance in young men with the same symptoms as andropause.
This condition is related to reduced fertility.
Advil and Motrin are two brand names for ibuprofen, an over-the-counter pain reliever. CNN contacted Pfizer and Johnson & Johnson, manufacturers of both brands, for comments.
This new study is a continuation of research undertaken with pregnant women, explains Bernard Jégou, co-author and director of the Research Institute of Environmental Health and Occupational Health in France.
With the help of scientists from the University Hospital of Rennes, David Moberg Kristensen in Denmark and researchers from LABERCA in Nantes, the authors conducted a clinical trial involving 31 male and female sports volunteers between the ages of 18 and 35, half of whom took ibuprofen. analyzed cultures of human testes fragments exposed to ibuprofen and cultures of an immortalized line of human cells.
The researchers found that taking 1200 mg / day of ibuprofen for 6 weeks acted as endocrine disruptors. In detail :
– When men have been exposed to ibuprofen, levels of pituitary hormone called luteinizing hormone (LH) rise strongly, this hormone plays a key role in controlling testosterone production.
– direct effects on the production of testosterone could be put forward.
The production of testicular prostaglandins is blocked by ibuprofen in ex vivo and in vitro tests.
Jégou and a team of French and Danish researchers studied the health effects when a future mother took one of three mild pain relievers found in drug vaults around the world: aspirin, acetaminophen (also known as the name paracetamol and sold under the trade name Tylenol) and ibuprofen.
Their first experiments, published in several articles, showed that when taken during the pregnancy, these three drugs affected the testicles of the male babies.
The specialists are however reassuring. They insist that the benefits are much greater than the risks for patients who need this medication on a daily basis.
On the other hand, “the preventive use among athletes does not make any sense,” insists Bernard Jégou. In addition to being useless, it exposes them to kidney risks, cardiovascular and digestive bleeding.