Barbara, 92 years old, served as the U.S. first lady between 1989 and 1993.
She has been in and out of hospital over the past year, and is reported to be battling with Chronic Obstructive Pulmonary Disease (COPD), and congestive heart failure.
A source told CNN that she is being cared for at her home in Houston, and that she had decided not to go back to hospital.
The office of former President George H. W. Bush released a statement, confirming after a “recent series of hospitalizations,” she has decided against seeking additional medical help.
“It will not surprise those who know her that Barbara Bush has been a rock in the face of her failing health, worrying not for herself — thanks to her abiding faith — but for others. She is surrounded by a family she adores, and appreciates the many kind messages and especially the prayers she is receiving,” the statement continued.
The Bushes have been married for 73 years.
Barbara is the only living wife of one former President and the mother of another former President.