In the best evidence of natural methods that make cell regenerating in organs and bodies, there was a study of 5th June in Cell Stem Cell said that long periods of fasting keep immunity good and safe and protect it from damage – like chemo. Also this promotes immunity regenerating while cells are shifted from one to another renew state.
For both mice and humans Phase 1 clinical trials with patients of chemo, long fasting periods lowered the white cells in blood. For mice, fasting made a regeneration flip switch and changed signal paths for hematopoietic stem cells. Those cells generate blood and immunity.
We cannot say that long fasting periods are giving amazing effects in long stem cell regeneration in hematopoietic systems according to Valter Longo.
This study also has implications for healthy aging, i.e. the immunity decline makes susceptibility increased to diseases with age. By defining how long fasting will take place, from no food for 4 days to even 6 months – results in killing of bad immunity cells and making new ones. This research also implicates chemo tolerance and those with immunity flaws and issues, autoimmune problems too.
Longo added that the amazing effect of fasting cannot be predicted in the stem cell renewal of hematopoietic systems. The Gerontology professor of Biological Sciences, USC Davis School of Gerontology, director of USC longevity institute also added to this same thesis. Longo had a joint meeting at USC Dornsife College of Letters, Art and Sciences.
While starving, we save energy and one thing with this Is recycling unneeded cells or damaged cells, adds Longo. We notice that in both humans and animals, with fasting, white blood cells can reduce. Then you eat again and they get back. Why and what is this?
THE FASTING CYCLE
Longer fasting periods makes us store more glucose, fat and ketones. Also there is a breakdown of white cells too. Longo compares this to plane with excess cargo.
During every fasting cycle, white cells depletion makes changes that promote stem cells renewal and new immunity cells. Or, longer fasting periods reduce the PKA enzyme, discovered by Longo and the team in another study for regulating stem cells renewal and also pluripotency i.e. the potential of a cell to turn into various cells. Long fasting also lowers IGF-1 levels, growth hormone linked to aging, tumors and cancer.
The PKA gene is the key for shutting down in order to make cells go in renewal mode. This is a green light for cells to start proliferation and remake the whole system, said Longo also linking this to the clinical applications that imitate long fasting for renewal of immunity. Also the good news is that the body removes old parts or damaged ones, inefficient – all with fasting. If you have a damaged chemo system, start this and have a new immunity in no time.
Chemo might save lives but it makes more damage overall to the immunity than before. These results said that fasting can mitigate bad effects of chemo. Added co-author Tanya Dorff which is assistant professor of clinical medicine in USC Norris Comprehensive Cancer Center and Hospital. It was added that more studies in clinics are needed and any diet process must be monitored by a doctor.
We examine the chance that the effects can apply to many organs and systems besides the immune one. Longo’s lab is making another research with diet issues and stem cells renewal for both humans and animals.
This study was affirmed by the National Institute of Aging of the National Institutes of Health (grant AG20642, AG025135, P01AG34906). This trial was also supported by V Foundation and National Cancer Institute of the National Institutes for Health (P30CA014089).
The primary study author was Chia Wei-Cheng. The others or co-authors are: Gregor Adams and Ben Lam, also Xiaoying Zhou – Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research of USC.
Stefano Da Sacco and Laura Perin-Saban Research Institute at Children’s Hospital Los Angeles.
USC Davis and Min Wei, David Quinn and Dorff- Keck School of Medicine USC, John Kopchik-University Ohio, and Mario Mirisola- University Palermo