The city is experiencing a gradual return to normal life, having recorded nearly no new infections since late March.
The lifting of the lockdown has greenlighted the resumption of inbound and outbound travel, though the city remains vigilant.
The lifting of the lockdown takes effect from Wednesday, April 8, two months since the lockdown was imposed.
Over 40,000 medics from over 32 provinces and municipalities were dispatched to Hubei Province to save lives.
The reduction of COVID-19 cases in Wuhan prompted praise from the World Health Organization (WHO) Director-General Tedros Adhanom.
Tedros said the city provides hope for the rest of the world that even the most severe situation of COVID-19 can be turned around.