The draw, held at the CAF headquarters in Cairo, involved 28 teams which are ranked lowest in the latest FIFA/Coca-Cola Ranking released in July.
The two-leg preliminary matches will be played between September 2 and September 10 2019.
The teams from Pot 2 were drawn to play the first leg at home while the teams from Pot 1 will host the second leg.
The winners of the preliminary round will join the continent’s 26 exempted teams in the group stage of the qualifiers.
There will be 10 groups of four teams. The group winners will then be drawn to play against each other in a two-legged tie with the five winners eventually advancing to represent Africa at the World Cup.
The preliminary round qualifiers in full are as follows:
Ethiopia v Lesotho
Somalia v Zimbabwe
Eritrea v Namibia
Burundi v Tanzania
Djibouti v eSwatini
Botswana v Malawi
Gambia v Angola
Liberia v Sierra Leone
Mauritius v Mozambique
Sao Tome e Principe v Guinea Bissau
South Sudan v Equatorial Guinea
Comoros v Togo
Chad v Sudan
Seychelles v Rwanda