The southern African country has so far administered about 31,000 doses of the AstraZeneca vaccine, the only vaccine it has started rolling out.
India donated 30,000 doses of the vaccine that were manufactured by the Serum Institute of India (SII), and Botswana bought 33,000 doses that were made in South Korea from the global vaccine distribution scheme COVAX.
The two people who died had taken the shots made in India.
AstraZeneca and the SII did not immediately respond to requests for comment from Reuters. Botswana’s health ministry did not say how the people died.
Millions of doses of the AstraZeneca shot have been safely administered around the world. The European Medicines Agency received reports of 169 cases of the rare brain blood clot by early April, after 34 million doses had been administered, Sabine Straus, chair of the EMA’s safety committee, said.
Most of the cases reported had occurred in women under 60.
The Botswana health ministry said in a statement late on Sunday that the two deaths were of elderly people. It did not elaborate. The AstraZeneca doses were made in India and are being distributed under the brand name COVISHIELD.
“The ministry has referred the matter to the regulator being BOMRA for immediate investigation. It is expected that BOMRA investigation will seek to establish the cause of two deaths as well as whether they are in any way linked to the COVID vaccine which was administered,” the statement read.