The rapper, never shy about expressing himself, made the comments in passing during one of two free-flowing interviews he gave as he promotes two upcoming albums.
“You hear about slavery for 400 years. For 400 years? That sounds like a choice,” West told TMZ Live, the broadcast wing of the celebrity gossip site.
West elaborated little on his statement but appeared to be drawing a parallel to how he is presumed to hold certain views as an African American artist.
“We’re mentally in prison. I like the word ‘prison’ because slavery is too direct to the idea of blacks. Like Holocaust is Jews, slavery is blacks,” West said.
West’s remarks immediately sparked an uproar on Twitter and he was taken to task live by a TMZ employee who said he was “appalled”.
The 40-year-old rapper, designer, and husband of reality television star Kim Kardashian re-emerged last month after a year-long absence that followed a purported mental breakdown.
He enraged many fellow artists — but was embraced by conservative commentators — as he praised US President Donald Trump, who has since cited the rapper’s words as evidence of minority support.
In a separate interview with radio host Charlamagne Tha God, West said he had not followed Trump’s policies but “when I see an outsider infiltrate, I connect with that”.
West said he was upset that former US president Barack Obama invited other rappers to the White House such as Kendrick Lamar and Jay-Z.
Obama, in off-record small talk with a reporter in 2009, called West a “jackass” after the rapper disrupted the MTV Video Music Awards to say that Taylor Swift did not deserve her prize.
“You know, he never called me to apologize,” West said, explaining that Obama had met him and his mother before being elected president.
“The same person who sat down with me and my mom, I think should have communicated with me directly.”