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Alabama Man Lynndrick Holmes Becomes First in the State to be Freed of Sickle Cell After Gene Therapy

An Alabama man is free of sickle cell disease after receiving gene therapy for 2 years as part of a clinical trial.

Lynndrick Holmes, 29, of Mobile, says he feels “amazing” after taking part in a study at the National Institutes of Health in Bethesda, MD.

“Sickle cell is like a stalker — you don’t know when he’s watching or what he’s planning,” says Holmes. “But now I feel amazing. I feel incredible.”

Sickle cell disease, which affects about 100,000 Americans, is a group of genetic disorders that cause red blood cells to become hard and sticky, taking on the form of a sickle, according to the CDC.

When these cells travel through small blood vessels, they can get stuck, causing pain, infection, and stroke.

There may be a new potential sickle cell breakthrough for those who suffer with the disease.

According to the National Institutes of Health, a Mobile man is the first Alabamian to become sickle cell free through a new gene therapy clinical trial they conducted.

For two years, Lynndrick Holmes says he underwent a gene therapy treatment at NIH in Washington, D.C.

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“It feels amazing,” he said. “I didn’t know how bad it was living with sickle cell until I got cured. Once I got cured, I was like, ‘I can’t believe I was living like that and I was expected to live out the rest of my life like that.'” (WPMI)

According to NIH, the treatment involved taking stem cells from his bone marrow, fixing the gene that causes his cells to sickle and reinserting that gene using the H-I-V virus; minus the parts of the virus that cause infection. That last part of the process happens after patients undergo chemotherapy to prepare for the introduction of the new cells.

Holmes completed his therapy in March and he’s now sickle cell free. Researchers hope the therapy will become a cure.

Those who suffer with sickle cell anemia deal with intense pain when red blood cells become “sickle-shaped.” They clog blood vessels and starve organs of oxygen.

Holmes says at first he was just surviving but now he’s living.

“It feels amazing,” he said. “I didn’t know how bad it was living with sickle cell until I got cured. Once I got cured, I was like, ‘I can’t believe I was living like that and I was expected to live out the rest of my life like that.'”

Doctors say it takes about five years without complication to declare a patient “cured” of sickle cell.

According to the NIH, the trial has about 50 slots, most have been filled already. Two of those patients will undergo the therapy at University of Alabama at Birmingham.

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Written by How Africa

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